• Users Online:222
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 

 Table of Contents  
EURO EUS MEETING
Year : 2014  |  Volume : 3  |  Issue : 5  |  Page : 2-3

Endoscopic ultrasound-guided needle confocal laser endomicroscopy in pancreatic masses


1 Copenhagen University Hospital Herlev, Herlev, Denmark
2 Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania
3 Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Romania

Date of Web Publication27-Mar-2014

Correspondence Address:
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

How to cite this article:
Karstensen J, Cartana T, Pia K, Saftoiu A, Vilmann P. Endoscopic ultrasound-guided needle confocal laser endomicroscopy in pancreatic masses . Endosc Ultrasound 2014;3, Suppl S1:2-3

How to cite this URL:
Karstensen J, Cartana T, Pia K, Saftoiu A, Vilmann P. Endoscopic ultrasound-guided needle confocal laser endomicroscopy in pancreatic masses . Endosc Ultrasound [serial online] 2014 [cited 2020 Jan 23];3, Suppl S1:2-3. Available from: http://www.eusjournal.com/text.asp?2014/3/5/2/129486

Introduction: Endoscopic ultrasound (EUS) is an established tool in diagnosing pancreatic masses and enables guided fine-needle aspiration (FNA). Confocal laser endomicroscopy (CLE) has allowed in vivo microscopic analysis during on-going endoscopy. Recently, CLE has gone beyond luminal indications with the development of a new microprobe (nCLE). The aim of this case series was to study the feasibility of EUS-guided nCLE and to correlate the findings with microscopy.

Methods: A total of 25 patients with pancreatic masses were included. During the procedure, an nCLE fiber preloaded into a 19 gauge FNA needle was advanced into the lesion under EUS guidance. Fluorescein was administered intravenously and imaging performed. Afterwards EUS-FNA was performed in the same location. Safety and feasibility were evaluated and CLE structures were registered and correlated to the standard hematoxylin and eosin cytopathology specimens. Moreover, additional topical acriflavine-enhanced ex vivo examinations on fresh pancreatic specimens were conducted.

Results: EUS-guided nCLE procedures were accomplished in all patients. No adverse advents were registered. Furthermore, it was feasible to do nCLE inside pathological lesions and relatively easy to visualize organ specific tissue. Despite selecting predefined structures the diagnostic value was limited mainly due to the missing ability to elucidate the cell nuclei, In the ex vivo examinations, where acriflavine was administered topically on excised pancreatic tissue, the nuclei were clearly visualized, thus increasing the diagnostic value.

Conclusion: EUS-guided nCLE procedures on focal pancreatic masses are feasible and safe, but the diagnostic value seems limited. Thus, further studies using different contrast agents are required to optimize the diagnostic accuracy.

Status of the presenting author: Chief resident

The authors declare: No significant relationship.




 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article

 Article Access Statistics
    Viewed753    
    Printed19    
    Emailed0    
    PDF Downloaded166    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]