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REVIEW ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 5  |  Page : 307-314

Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis


1 Department of Surgery, Endoscopy Unit, Herlev University Hospital, Herlev, Denmark
2 Department of Surgery, Endoscopy Unit, Herlev University Hospital, Herlev, Denmark; Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3 Department of Haematology, Herlev University Hospital, Herlev, Denmark
4 Department of Surgery, Zealand University Hospital, University of Copenhagen, Køge, Denmark

Correspondence Address:
Marie Louise Malmstrom
Department of Surgery, Endoscopy Unit, Herlev University Hospital, Herlev, Denmark

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2303-9027.191610

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Background and Objectives: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum. Patients and Methods: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard. Outcome measures were T- and N-staging accuracies. Articles were searched in PubMed, Web of Science, The Cochrane Library, and EMBASE. Results: Six studies were identified comparing EUS staging of colonic cancer to histopathology. The pooled-staging sensitivity and specificity were 0.90 and 0.98 for T1 tumors, 0.67 and 0.96 for T2 tumors, and 0.97 and 0.83 for T3/T4 tumors, respectively. Sensitivity and specificity for N + disease were 0.59 and 0.78, respectively. Conclusions: EUS is a feasible method for T-staging of cancers of the colon proximal to the rectum. The accuracy of lymph node staging needs to be verified by prospective multicenter studies including larger patient populations.


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