• Users Online:4573
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 

 Table of Contents  
Year : 2017  |  Volume : 6  |  Issue : 8  |  Page : 48-49

Solid pseudopapillary neoplasms: A case series and review of literature

1 Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt
2 Assiut University, Assiut, Egypt
3 Egypt Air Hospital, Cairo, Egypt
4 Hospital Das Clinicas, Sao Paulo, Brazil

Date of Web Publication16-Nov-2017

Correspondence Address:
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2303-9027.218442

Rights and Permissions

Solid pseudopapillary neoplasm (SPPN) of the pancreas is a rare tumor entity that arises from different pancreatic parts constitutes up to 2.5% of all pancreatic neoplasms. We addressed special focus on the general descriptive features of SPPNs regarding age, gender, symptoms, diagnostic tools, pathological features, surgery, and outcome. SPPN has low malignant potential. It usually discovered incidentally with great predilection to occur in young women in about 90% of reported cases. SPPNs exhibit benign characteristics in most of cases reported with low tendency toward malignant behavior. Tumor size may reach up to 10 cm and the prevalent sites of tumor occurrence are the head and tail of the pancreas comprising 40% and 30%, respectively. SPPNs tend to arise as single pancreatic mass, but some reported cases of multicentric SPPN. Endoscopic ultrasound (EUS)-guided fine needle aspiration (EUS-FNA) is used as a preoperative diagnostic tool with sensitivity and specificity of 90% and 94%, respectively. Surgical resection is the standard of care for treatment of such neoplasms as it achieves cure and prolongs patient survival. Long-term prognosis is evidently excellent with 5-year survival rates ranging 95%–97%. In addition, 10-year survival may be as high as 90%, but these data are limited. Nonresectable tumors are treated by surgical debulking. In our series, we identified 18 cases of SPPN confirmed by histopathological examination. Female to male ratio is 9:1, and mean age was 29 with an average of 5.5 years. The oldest of our patients was a 70-year-old male. All patients presented with abdominal pains; some presented with anorexia and weight loss. EUS showed a soft tissue mass with multiple cystic areas that represented areas of internal hemorrhage. The size ranged from 2 cm up to 10 cm. Eight masses were located in the body, 7 in the head, 2 in the tail, and only one case in the uncinate process. The cytopathological study demonstrated single cells, small loose clusters, and scattered intact papillary structures with delicate fibrovascular cores, finely granular cytoplasm, and nuclei with fine chromatin. No distant metastasis was observed. EUS-FNA was done in all cases using a 22G needle and revealed SPPN in all cases. Distal pancreatectomy or modified Whipple operation was done and final histopathology confirmed the diagnosis. Only one patient operated by Whipple resection complicated by postoperative abdominal sepsis and died 2 weeks later. Follow-up for at least 2 years for the rest of the patients revealed no recurrence.

Keywords: Endoscopic ultrasound, endoscopic ultrasound-guided fine needle aspiration, solid pseudopapillary neoplasm, solid pseudopapillary tumor

How to cite this article:
Okasha H, El-Nady M, Abbas W, Shiha MS, Moura D. Solid pseudopapillary neoplasms: A case series and review of literature. Endosc Ultrasound 2017;6, Suppl S2:48-9

How to cite this URL:
Okasha H, El-Nady M, Abbas W, Shiha MS, Moura D. Solid pseudopapillary neoplasms: A case series and review of literature. Endosc Ultrasound [serial online] 2017 [cited 2020 Aug 4];6, Suppl S2:48-9. Available from: http://www.eusjournal.com/text.asp?2017/6/8/48/218442



Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article

 Article Access Statistics
    PDF Downloaded77    
    Comments [Add]    

Recommend this journal