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ABSTRACT
Year : 2017  |  Volume : 6  |  Issue : 8  |  Page : 56

Endoscopic ultrasound-guided needle-based confocal laser endomicroscopy in pancreatic neoplasms: A single-center experience in China


1 Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, China
2 Department of Gastroenterology, Huashan Hospital, Fudan University, Shanghai, China
3 Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China
4 Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai, China
5 Endoscopic Center, Huashan Hospital, Fudan University, Shanghai, China

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2303-9027.218435

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Objective: The objective of the study is to investigate the application of endoscopic ultrasound-guided needle-based confocal laser endomicroscopy (EUS-nCLE) in the diagnosis of pancreatic neoplasms. Methods: Patients with pancreatic neoplasms were diagnosed by endoscopic ultrasound and punctured by 19G needle; Cellvizio AQ-Flex19 confocal microprobe was implanted through the needle. The diagnostic yield and complication were evaluated and compared with pathology. Results: A total of 28 patients successfully underwent EUS-nCLE examination, including serous cystadenoma (n = 5), mucinous cystadenoma (n = 3), intraductal papillary mucinous neoplasms (n = 3), pseudocyst (n = 1), ductal adenocarcinoma (n = 10), neuroendocrine tumors (1), solid pseudopapillary tumor (n = 2), chronic pancreatitis (n = 2), and lymphoma (n = 1). High-quality images were obtained in all the patients. The diagnostic yield in 26 patients with pathology was 73.1% (19/26) and the specificity of serous cystic neoplasm (SCN) and intraductal papillary mucinous neoplasm (IPMN) was 100% (7/7). The complications, mostly pancreatitis and intracystic hemorrhage, were occurred in 10.7% (3/28) patients. Conclusion: EUS-nCLE is a safe and feasible method in the diagnosis of pancreatic neoplasms and shows high specificity in SCN and IPMN.


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