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ORIGINAL ARTICLE
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Prospective, multicenter, observational study of tissue acquisition through EUS-guided fine-needle biopsy using a 25G Franseen needle


1 Department of Gastroenterology and Hepatology, Hokkaido University, Faculty of Medicine and Graduate School of Medicine, Sapporo, Japan
2 Department of Gastroenterology and Hepatology, Hokkaido University, Faculty of Medicine and Graduate School of Medicine; Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan
3 Center for Gastroenterology, Teine-Keijinkai Hospital, Sapporo, Japan
4 Department of Gastroenterology, Hokkaido Medical Center, Sapporo, Japan
5 Department of Gastroenterology, Tonan Hospital, Sapporo, Japan
6 Department of Gastroenterology, NTT East Sapporo Hospital, Sapporo, Japan
7 Department of Gastroenterology, Tomakomai City Hospital, Tomakomai, Japan
8 Department of Internal Medicine, Kushiro Rosai Hospital, Kushiro, Japan
9 Department of Gastroenterology and Hepatology, Hakodate Municipal Hospital, Hakodate, Japan
10 Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan
11 ,

Correspondence Address:
Masaki Kuwatani,
Department of Gastroenterology and Hepatology, Hokkaido University, Faculty of Medicine and Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638
Japan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/eus.eus_66_18

PMID: 30880724

Background: Recently, EUS-guided fine-needle biopsy (EUS-FNB) using a Franseen needle was developed for histological tissue acquisition. However, the yield of a 25G Franseen needle when acquiring histological core tissue has been unclear. Patients and Methods: We performed a prospective, multicenter, and observational cohort study that included 100 solid lesions scheduled for EUS-FNB using a 25G Franseen needle at eight centers in Hokkaido, Japan. Only EUS-FNB specimens acquired at the first pass were evaluated without a rapid on-site evaluation. The tissue acquisition rate, acquisition rate of an adequate specimen for histological assessment, the quality of tissue sample, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), diagnostic accuracy, and adverse events were evaluated. Results: We analyzed a total of 100 solid lesions in 100 patients. The patients were 57 males and 43 females with a median age of 70 years. The technical success rate was 100%. The tissue acquisition rate was 95.0%. The acquisition rate of an adequate specimen for histological assessment was 82.0%. The sensitivity, specificity, PPV, NPV, and diagnostic accuracy were 87.0%, 100%, 100%, 40.0%, and 88.0%, respectively. The adverse event rate was 1.0%, and it was reported in only one patient who had a moderate pancreatic fistula. Conclusions: EUS-FNB using the 25G Franseen needle was feasible, and adequate histological core tissue samples were acquired with this method.


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    -  Sugiura R
    -  Kuwatani M
    -  Yane K
    -  Taya Y
    -  Ihara H
    -  Onodera M
    -  Eto K
    -  Sano I
    -  Kudo T
    -  Mitsuhashi T
    -  Katanuma A
    -  Sakamoto N
    -  Hokkaido Interventional EUS/ERCP study (HONEST) group
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