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The difference in histological yield between 19G EUS-FNA and EUS-fine-needle biopsy needles


1 Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore
2 Department of Laboratory Medicine, Changi General Hospital, Singapore

Correspondence Address:
Tiing Leong Ang,
Department of Gastroenterology and Hepatology, Changi General Hospital, 2 Simei Street 3, Singapore 529889

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/eus.eus_12_19

Background and Objective: EUS-guided fine-needle biopsy (EUS-FNB) with acquisition of tissue core is possible with the use of 19G fine-needle aspiration (FNA) and dedicated biopsy needles. Published data of direct comparisons between biopsy needles are more limited compared to the abundant data comparing EUS-FNA with EUS-FNB. We performed a retrospective study to determine the difference in histologic yield between 19G FNA needle and EUS-FNB needles in patients with solid masses. Materials and Methods: Consecutive patients who underwent EUS-FNB of solid masses from January 2014 to July 2018 were identified from a database. The difference in histologic yield between needles was analyzed. Results: A total of 159 patients underwent 179 EUS-FNB procedures (median of 2 needle passes [range: 1–4]). The use of 19G FNA, 19G, 20G, and 22G FNB needles allowed acquisition of a histologic core in 67.4% (29/43), 72.5% (29/40), 82.1% (46/56), and 75.9% (22/29), respectively (P = 0.368). A significant difference in the yield of histologic core was detected when 19G FNA needle was compared with 22G Acquire™ FNB needle (67.4% [29/43] vs. 94.1% [16/17], P = 0.032). The presence of histologic core was significantly associated with a positive diagnosis (95.6% vs. 30.2%, P < 0.0001). Conclusion: EUS-FNB with acquisition of histologic core improved the diagnostic yield. Dedicated FNB needles appeared to achieve a higher yield of histologic core compared to 19G FNA needles.


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    -  Ang TL
    -  Li JW
    -  Kwek AB
    -  Thurairajah PH
    -  Wang LM
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