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Changes in tumor vascularity depicted by contrast-enhanced EUS as a predictor of prognosis and treatment efficacy in patients with unresectable pancreatic cancer (PEACE): A study protocol

1 Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Craiova, Romania
2 Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA
3 Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan
4 Pancreato-Biliary Endoscopy and Endosonography Division, San Raffaele Scientific Institute, Vita Salute San Raffaele University Milan, Milan, Italy
5 Endoscopy Unit, Paoli Calmettes Institute, Marseille, France
6 Research Center of Gastroenterology and Hepatology Craiova, University of Medicine and Pharmacy Craiova, Craiova, Romania; Department of Gastroenterology, Hepatology and Nutrition, MD Anderson Cancer Center, Houston, Texas, USA
7 Department of Gastroenterology, Ponderas Academic Hospital, Bucharest, Romania
8 Medical Department, Caritas-Krankenhaus, Uhlandstr 7, D-97980 Bad Mergentheim, Germany
9 Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
10 Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostella, Santiago, Spain
11 Department of Gastroenterology, Helios Kliniken Meiningen, Meiningen, Germany
12 Department of Internal Medicine, Krankenhaus Maerkisch-Oderland, D-15344 Strausberg and Brandenburg Institute of Clinical Ultrasound at Medical University Brandenburg, Germany
13 Department of Gastroenterology, Central Clinical Emergency Military Hospital Dr. Carol Davila, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania
14 Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore
15 HPB Unit, Freeman Hospital, Newcastle upon Tyne, London, UK
16 University College London Institute for Liver and Digestive Health, Royal Free Hospital Campus, London, UK
17 Tel Aviv Souraski Medical Center, Invasive Endoscopy Unit, Gastroenterology Institute, Tel Aviv, Israel
18 Regional Institute of Gastroenterology and Hepatology, University of Medicine and Pharmacy “Iuliu Hațieganu,” Cluj-Napoca, Romania
19 Asan Medical Center, Seoul, South Korea
20 Endoscopy Center, Liaoning Engineering Technology Research Center of Diagnosis and Treatment of Digestive Endoscopy, Shengjing Hospital of China Medical University, Shenyang, China
21 Gastrointestinal Unit, Copenhagen University Hospital Herlev, Herlev, Denmark
22 Center for Endoscopic Research and Therapeutics, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA
23 Carilion Clinic Roanoke, Roanoke, USA

Correspondence Address:
Irina M Cazacu,
Department of Gastroenterology, Hepatology and Nutrition-Unit 1466, UT MD Anderson Cancer Center, 1515 Hol-combe Blvd., Houston, Texa

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/eus.eus_16_19

PMID: 31249159

Patients with unresectable pancreatic cancer have a poor prognosis. The analysis of prognostic factors before treatment may be helpful in determining the best therapeutic strategies. The aim of the PEACE study is to assess the vascularity of pancreatic malignant tumors using contrast-enhanced harmonic EUS (CEH-EUS) and to clarify the prognostic value of tumor vascularity in patients with locally advanced and metastatic pancreatic cancer. Hereby, we present the protocol of a prospective, nonrandomized, single-arm, multicenter study aiming to assess changes in tumor vascularity using CEH-EUS before and 2 months after treatment initiation in patients with unresectable, locally advanced/metastatic pancreatic cancer and to examine the correlation between vascular changes and treatment response, progression-free survival, and overall survival.

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