Endoscopic Ultrasound

REVIEW ARTICLE
Year
: 2016  |  Volume : 5  |  Issue : 5  |  Page : 307--314

Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis


Marie Louise Malmstrom1, Adrian Saftoiu2, Peter Vilmann1, Tobias Wirenfeldt Klausen3, Ismail Gogenur4 
1 Department of Surgery, Endoscopy Unit, Herlev University Hospital, Herlev, Denmark
2 Department of Surgery, Endoscopy Unit, Herlev University Hospital, Herlev, Denmark; Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
3 Department of Haematology, Herlev University Hospital, Herlev, Denmark
4 Department of Surgery, Zealand University Hospital, University of Copenhagen, Køge, Denmark

Correspondence Address:
Marie Louise Malmstrom
Department of Surgery, Endoscopy Unit, Herlev University Hospital, Herlev, Denmark

Background and Objectives: Treatment of colonic cancer patients is highly dependent on the depth of tumor invasion (T-stage) as well as the extension of lymph node involvement (N-stage). We aimed to systematically review the accuracy of endoscopic ultrasound (EUS) for staging of colonic cancer proximal to the rectum. Patients and Methods: Men and women with colonic adenocarcinomas were included in the study. EUS staging was compared to histopathology as the gold standard. Outcome measures were T- and N-staging accuracies. Articles were searched in PubMed, Web of Science, The Cochrane Library, and EMBASE. Results: Six studies were identified comparing EUS staging of colonic cancer to histopathology. The pooled-staging sensitivity and specificity were 0.90 and 0.98 for T1 tumors, 0.67 and 0.96 for T2 tumors, and 0.97 and 0.83 for T3/T4 tumors, respectively. Sensitivity and specificity for N + disease were 0.59 and 0.78, respectively. Conclusions: EUS is a feasible method for T-staging of cancers of the colon proximal to the rectum. The accuracy of lymph node staging needs to be verified by prospective multicenter studies including larger patient populations.


How to cite this article:
Malmstrom ML, Saftoiu A, Vilmann P, Klausen TW, Gogenur I. Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis.Endosc Ultrasound 2016;5:307-314


How to cite this URL:
Malmstrom ML, Saftoiu A, Vilmann P, Klausen TW, Gogenur I. Endoscopic ultrasound for staging of colonic cancer proximal to the rectum: A systematic review and meta-analysis. Endosc Ultrasound [serial online] 2016 [cited 2020 Aug 5 ];5:307-314
Available from: http://www.eusjournal.com/article.asp?issn=2303-9027;year=2016;volume=5;issue=5;spage=307;epage=314;aulast=Malmstrom;type=0