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Year : 2014  |  Volume : 3  |  Issue : 5  |  Page : 10-11

Endosonographic features of unicentric Castleman Disease

1 Iaso General Hospital, Cholargos, Greece
2 Iaso General Hospital, Athens, Greece
3 Evaggelismos General Hospital, Cholargos, Greece

Date of Web Publication27-Mar-2014

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Source of Support: None, Conflict of Interest: None

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How to cite this article:
Panagiotakopoulos D, Mouchtouris A, Zarakostas M, Rontogianni D, Athanasiadou P. Endosonographic features of unicentric Castleman Disease. Endosc Ultrasound 2014;3, Suppl S1:10-1

How to cite this URL:
Panagiotakopoulos D, Mouchtouris A, Zarakostas M, Rontogianni D, Athanasiadou P. Endosonographic features of unicentric Castleman Disease. Endosc Ultrasound [serial online] 2014 [cited 2021 Jan 16];3, Suppl S1:10-1. Available from: http://www.eusjournal.com/text.asp?2014/3/5/10/129513

Background: Castleman disease (CD) is a rare lymphoproliferative disorder most frequently occurring in the mediastinum. Peripancreatic forms are less frequent. Few cases of endoscopic ultrasonography-fine-needle aspiration (EUS-FNA) findings of this lesion have been reported, where no real-time tissue elastography (RTTE) has been described in the literature to our knowledge.

Methods: We describe the endosonographic, elastographic, cytologic and immunocytochemistry findings in two cases of unicentric CD of the hyaline vascular variant.

Results: Two females, aged 41 and 34 year were referred to our hospital for further EUS evaluation of a peripancreatic mass found incidentally on computed tomography. EUS examination revealed around, well-demarcated, uniformly hypoechoic mass measuring 52 and 23 mm respectively, with smaller adjacent hypoechoic lymph nodes. Doppler examination revealed intense peripheral vascularity, together with prominent penetrating feeding vessels entering a distinct hilum. RTTE revealed a relatively homogenous soft elastographic pattern. EUS-FNA provided smears with clusters of lymphocytes in a hemorrhagic background. Cell block preparation showed immature lymphocytes surrounding lymphocyte-poor centers with vascular proliferation. Immunohistochemical staining of the cell block sections showed CD45-leukocyte common antigen, CD20, CD23, CD79a, Bcl-2 and CD5 positivity in small lymphocytes. Cytology was suggestive of non-Hodgkin's lymphoma. Surgical excision was performed in both cases and histopathology was consistent with CD of the hyaline vascular type.

Conclusion: The echo features of a solitary hypoechoic homogenous well-demarcated mass with prominent vasculature and increased elasticity should raise the possibility of unicentric CD. EUS-FNA usually cannot make a definitive distinction from certain kinds of lymphoma.

Status of the presenting author: Chief resident.

The authors declare: No significant relationship.


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