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| EURO EUS MEETING |
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| Year : 2014 | Volume
: 3
| Issue : 5 | Page : 2-3 |
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Endoscopic ultrasound-guided needle confocal laser endomicroscopy in pancreatic masses
J Karstensen1, T Cartana2, K Pia1, A Saftoiu3, P Vilmann1
1 Copenhagen University Hospital Herlev, Herlev, Denmark
2 Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania
3 Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Romania
| Date of Web Publication | 27-Mar-2014 |
Correspondence Address:
 Source of Support: None, Conflict of Interest: None  | Check |
How to cite this article:
Karstensen J, Cartana T, Pia K, Saftoiu A, Vilmann P. Endoscopic ultrasound-guided needle confocal laser endomicroscopy in pancreatic masses
. Endosc Ultrasound 2014;3, Suppl S1:2-3 |
How to cite this URL:
Karstensen J, Cartana T, Pia K, Saftoiu A, Vilmann P. Endoscopic ultrasound-guided needle confocal laser endomicroscopy in pancreatic masses
. Endosc Ultrasound [serial online] 2014 [cited 2021 Jan 16];3, Suppl S1:2-3. Available from: http://www.eusjournal.com/text.asp?2014/3/5/2/129486 |
Introduction: Endoscopic ultrasound (EUS) is an established tool in diagnosing pancreatic masses and enables guided fine-needle aspiration (FNA). Confocal laser endomicroscopy (CLE) has allowed in vivo microscopic analysis during on-going endoscopy. Recently, CLE has gone beyond luminal indications with the development of a new microprobe (nCLE). The aim of this case series was to study the feasibility of EUS-guided nCLE and to correlate the findings with microscopy.
Methods: A total of 25 patients with pancreatic masses were included. During the procedure, an nCLE fiber preloaded into a 19 gauge FNA needle was advanced into the lesion under EUS guidance. Fluorescein was administered intravenously and imaging performed. Afterwards EUS-FNA was performed in the same location. Safety and feasibility were evaluated and CLE structures were registered and correlated to the standard hematoxylin and eosin cytopathology specimens. Moreover, additional topical acriflavine-enhanced ex vivo examinations on fresh pancreatic specimens were conducted.
Results: EUS-guided nCLE procedures were accomplished in all patients. No adverse advents were registered. Furthermore, it was feasible to do nCLE inside pathological lesions and relatively easy to visualize organ specific tissue. Despite selecting predefined structures the diagnostic value was limited mainly due to the missing ability to elucidate the cell nuclei, In the ex vivo examinations, where acriflavine was administered topically on excised pancreatic tissue, the nuclei were clearly visualized, thus increasing the diagnostic value.
Conclusion: EUS-guided nCLE procedures on focal pancreatic masses are feasible and safe, but the diagnostic value seems limited. Thus, further studies using different contrast agents are required to optimize the diagnostic accuracy.
Status of the presenting author: Chief resident
The authors declare: No significant relationship.
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