|
 
 |
| IMAGES AND VIDEOS |
|
| Year : 2017 | Volume
: 6
| Issue : 5 | Page : 340-342 |
|
A rare case of pancreatic metastasis of angiosarcoma: Diagnosed by endoscopic ultrasound-guided fine-needle aspiration and biopsy
Manoop S Bhutani1, Ayush Arora1, Uma Kundu2, Dipen Maru2
1 Department of Gastroenterology, Hepatology and Nutrition, UT MD Anderson Cancer Center, Houston, Texas, USA
2 Department of Pathology, UT MD Anderson Cancer Center, Houston, Texas, USA
| Date of Submission | 07-Nov-2016 |
| Date of Acceptance | 07-Nov-2016 |
| Date of Web Publication | 16-Oct-2017 |
Correspondence Address:
Manoop S Bhutani
Department of Gastroenterology, Hepatology and Nutrition, Unit 1466, UT MD Anderson Cancer Center, 1515, Holcombe Blvd., 77030-4009, Houston, Texas
USA
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2303-9027.216719
How to cite this article:
Bhutani MS, Arora A, Kundu U, Maru D. A rare case of pancreatic metastasis of angiosarcoma: Diagnosed by endoscopic ultrasound-guided fine-needle aspiration and biopsy. Endosc Ultrasound 2017;6:340-2 |
How to cite this URL:
Bhutani MS, Arora A, Kundu U, Maru D. A rare case of pancreatic metastasis of angiosarcoma: Diagnosed by endoscopic ultrasound-guided fine-needle aspiration and biopsy. Endosc Ultrasound [serial online] 2017 [cited 2021 Jan 16];6:340-2. Available from: http://www.eusjournal.com/text.asp?2017/6/5/340/216719 |
A 55-year-old female, with primary splenic angiosarcoma with metastatic lesions in liver, T-8 vertebra and left femur, status postsplenectomy, right hepatectomy and cholecystectomy, and multiple cycles of chemotherapy, was found to have a new 0.5 cm ill-defined attenuation focus in the body of pancreas on routine surveillance computed tomography (CT) scan. Follow-up of CT 2 months later revealed increase in size of the same mass to 0.8 cm [Figure 1], worrisome of progressive metastatic lesion from angiosarcoma. The patient was referred for endoscopic ultrasound (EUS)-guided fine-needle aspiration and biopsy (FNAB). On EUS [Figure 2], an 8 mm × 6 mm isoechoic rounded mass was seen in the pancreatic body. Transgastric EUS-guided fine-needle aspiration (two passes) and fine-needle core biopsy (two passes) were done using a 25 G, ProCore EUS needle (Cook). On cytology, specimens along with immunostains performed on the cell block sections showed that the neoplastic cells were positive for ERG and CD31 and focally/weakly positive for pan-cytokeratin. Immunohistochemical staining of the core biopsy revealed that the tumor cells were strongly positive for ERG (nuclear pattern), focally positive for CD31 and CD34, and negative for synaptophysin and chromogranin. This was consistent with metastatic angiosarcoma [Figure 3], [Figure 4], [Figure 5], [Figure 6]. | Figure 1: Computed tomography scan showing (arrow) a small, 8 mm, subtle, ill-defined mass in the pancreatic body
Click here to view |
 | Figure 2: Endoscopic ultrasound exam revealing the same lesion (arrows) that was subjected to endoscopic ultrasound-guided fine-needle aspiration and core biopsy
Click here to view |
 | Figure 3: Papanicolaou-stained smear shows a group of spindled to epithelioid cells with coarse chromatin pattern consistent with the patient's history of angiosarcoma
Click here to view |
 | Figure 4: H and E stain of a cell block preparation demonstrates a small of groups of neoplastic spindle cells
Click here to view |
 | Figure 5: Immunohistochemistry performed on the cell block preparation shows positive staining for CD31, consistent with angiosarcoma
Click here to view |
 | Figure 6: Immunohistochemistry performed on the cell block preparation shows positive staining for ERG, consistent with angiosarcoma
Click here to view |
Angiosarcomas are rare, malignant, and frequently fatal soft tissue tumors and may metastasize to almost all visceral organs including pancreas. Definitive diagnosis can be made only with immunochemistry, and hence, obtaining biopsy is of paramount importance. EUS-FNAB has previously been described for diagnosing angiosarcoma in suprarenal gland [1] and spleen [2] in two prior case reports. To our knowledge, we present the first case of EUS-FNAB use for diagnosis of angiosarcoma within the pancreas. Primary angiosarcoma in pancreas may present as acute pancreatitis and diagnosis may be missed if biopsy is not performed as described by Csiszkó et al.[3] and Seth et al.[4] separately in their case reports. We recommend keeping angiosarcoma as a possible rare differential while evaluating pancreatic masses and using EUS-guided FNAB with these well-evaluated core needles[5],[6] to confirm the diagnosis.
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient has given her consent for her images and other clinical information to be reported in the journal. The patients understand that her name and initial will not be published and due efforts will be made to conceal her identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
| References | |  |
| 1. | Chen X, Lagana SM, Poneros J, et al. Cytological diagnosis of angiosarcoma arising in an immunosuppressed patient 6 years after multi-visceral transplantation: A case report and literature review. Diagn Cytopathol 2014;42:884-9.  |
| 2. | Maeyashiki C, Nagata N, Uemura N. Angiosarcoma involving solid organs and the gastrointestinal tract with life-threatening bleeding. Case Rep Gastroenterol 2012;6:772-7. |
| 3. | Csiszkó A, László I, Palatka K, et al. Primary angiosarcoma of the pancreas mimicking severe acute pancreatitis – case report. Pancreatology 2015;15:84-7. |
| 4. | Seth AK, Argani P, Campbell KA. Angiosarcoma of the pancreas: Discussion of a rare epithelioid neoplasm. Pancreas 2008;37:230-1. |
| 5. | Berzosa M, Villa N, El-Serag HB, et al. Comparison of endoscopic ultrasound guided 22-gauge core needle with standard 25-gauge fine-needle aspiration for diagnosing solid pancreatic lesions. Endosc Ultrasound 2015;4:28-33. [ PUBMED] [Full text] |
| 6. | Adler DG, Witt B, Chadwick B, et al. Pathologic evaluation of a new endoscopic ultrasound needle designed to obtain core tissue samples: A pilot study. Endosc Ultrasound 2016;5:178-83. [ PUBMED] [Full text] |
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]
|
Search Pubmed for